In this talk, Dr. Shendure will describe our ongoing efforts to develop and apply new technologies aimed at reconstructing the entirety of mouse embryonic development at single cell resolution. A first approach that he is pursuing involves single cell profiling of whole embryos at successive timepoints, resulting in “snapshots” that must be pieced together analogous to a timelapse movie. A complementary approach that Dr. Shendure is also pursuing involves time-resolved molecular recording, essentially leveraging DNA as a substrate to write information that informs the reconstruction of cell lineage and other molecular events as they transpired over the course of a single embryo's development. Under these two strategies, Dr. Shendure will discuss progress and challenges towards the long-term dream of comprehensively modeling the entirety of mouse prenatal development, from a single cell zygote to a free-living pup. Register here.